Lupus & antiphospholipid syndrome
The impact of traditional cardiovascular risk factor control on 7-year follow-up atherosclerosis progression in systemic lupus erythematosus
Main finding · New plaque developmentResult — go to the resultOdds ratio 4.16 CI 1.22–14.19Authors' conclusion
Patients with SLE develop a rapid progression of atherosclerotic plaques which may be drastically reduced by CVRF target attainment according to ESC guidelines.
Study context
- Population
- Patients with SLE and age and sex-matched healthy controls with baseline carotid and femoral ultrasound in a cardiovascular research unit115 SLE patients invited
- Participants
- 86 vs 42
- Exposure
- SLE vs age and sex-matched healthy controls
- SLEn = 86
- Controlsn = 42reference
- Outcome
- New atherosclerotic plaque development (plaque progression) on carotid and femoral ultrasound
- Follow-up
- 7 years
Methodological details1:1 age and sex-matched healthy controls, carotid and femoral ultrasound, 7-year follow-up, adjusted for potential confounders
- 1:1 age and sex-matched healthy controls
- Carotid and femoral ultrasound
- 7-year follow-up
- Adjusted for potential confounders
Main finding
New plaque development
Odds ratio
4.16
CI 1.22–14.19
P = 0.023
Events by group
SLE
32
events
Controls
8
events
SLEvs Controls
OR 4.16 (CI 1.22–14.19); P = 0.023
As reported in the abstract
Observational data: associations, not effects.
Further findings
Plaque progression per modifiable cardiovascular risk factors (CVRF) fulfilling European Society of Cardiology (ESC) targets (multivariate regression) · 7 years
- OR per CVRF at ESC target: 0.56 (CI 0.34, 0.93), P = 0.026
Original publication
The impact of traditional cardiovascular risk factor control on 7-year follow-up atherosclerosis progression in systemic lupus erythematosus. Rheumatology (Oxford). Published 22 April 2023. doi:10.
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