Lupus & antiphospholipid syndrome
Sustained cardiovascular risk factor control is associated with reduced metabolic dysfunction-associated steatotic liver disease risk in SLE
Authors' conclusion
Femoral plaque progression and persistent IgG anti-beta2 glycoprotein I antibody positivity are independently associated with MASLD in SLE, while MASLD risk is halved for each additional CVRF target sustainedly attained.
Study context
- Population
- Patients with SLE (median age 53 years) and age- and sex-matched HCs who completed a 10-year carotid/femoral ultrasound follow-up; MASLD assessed by transient liver elastography
- Participants
- 77 vs 45
- Exposure
- SLE vs age/sex-matched HCs; associations between MASLD and CVRF burden in SLE
- SLEn = 77
- HCsn = 45reference
- Outcome
- Association between MASLD and traditional and disease-related cardiovascular risk factors (CVRFs) in SLE
Methodological detailsage- and sex-matched healthy controls, multivariate regression models, 10-year carotid/femoral ultrasound follow-up
- Age- and sex-matched healthy controls
- Multivariate regression models
- 10-year carotid/femoral ultrasound follow-up
Main finding
As reported in the abstract
MASLD risk per additional sustainedly achieved traditional CVRF target (blood pressure, lipids, smoking, physical activity, or body weight), in SLE · past 10 years
- MASLD risk reduced by 55% for each additional sustainedly achieved traditional CVRF target (OR)
- 0.45, P = 0.021
- Femoral plaque progression: higher risk for MASLD (3.6-fold, OR)
- 3.62, P = 0.047
- Consistent IgG anti-beta2glycoprotein I antibody positivity over the past 10 years: higher risk for MASLD (6.6-fold, OR)
- 6.58, P = 0.021
Observational data: associations, not effects.
Further findings
| Outcome | OR | P value |
|---|---|---|
| MASLD risk in SLE with femoral plaque progression3.6-fold higher risk | 3.62 | P = 0.047 |
| MASLD risk in SLE with consistent IgG anti-beta2glycoprotein I antibody positivity over past 10 years6.6-fold higher risk | 6.58 | P = 0.021 |
Original publication
Sustained cardiovascular risk factor control is associated with reduced metabolic dysfunction-associated steatotic liver disease risk in SLE. Rheumatology (Oxford). Published 11 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →