Lupus & antiphospholipid syndrome
Oxidised low-density lipoprotein and antibodies against oxidised low-density lipoprotein in patients with antiphospholipid syndrome
Authors' conclusion
This study indicates that the presence of anti-OxLDL may serve as potential markers for venous thrombosis in APS patients.
Study context
- Population
- Antiphospholipid syndrome (APS) patients and healthy controls, Peking University People's Hospital106 isolated thrombotic APS
- Participants
- 170 vs 39
- Exposure
- APS patients vs healthy controls
- APSn = 170
- Healthy controls (HC)n = 39reference
- Outcome
- OxLDL and anti-OxLDL (ELISA) and their clinical significance in APS
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
OxLDL titre
P < 0.001
Observational data: associations, not effects.
Further findings
OxLDL positivity rate
P < 0.001
Anti-OxLDL positivity rate
P < 0.001
Risk factor for venous thrombotic APS (multivariate logistic regression)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Anti-OxLDL positivityMultivariate logistic regression | 12.424 (1.108–139.330) | P = 0.041 | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | P value |
|---|---|
| LAC positivity in APS, by OxLDL level | P = 0.042 |
| Venous thrombosis in APS, by anti-OxLDL status | P = 0.008 |
| Coomb's test positivity in APS, by anti-OxLDL status | P = 0.049 |
- LAC positivity in APS, by oxidised low-density lipoprotein (OxLDL) level: Elevated OxLDL 68.0%
- LAC positivity in APS, by OxLDL level: Non-elevated OxLDL 45.0%
- Venous thrombosis in APS, by anti-OxLDL status: Positive anti-OxLDL 46.2%
- Venous thrombosis in APS, by anti-OxLDL status: Negative anti-OxLDL 18.5%
- Coomb's test positivity in APS, by anti-OxLDL status: Positive anti-OxLDL 52.6%
- Coomb's test positivity in APS, by anti-OxLDL status: Negative anti-OxLDL 76.2%
Original publication
Oxidised low-density lipoprotein and antibodies against oxidised low-density lipoprotein in patients with antiphospholipid syndrome. Clin Exp Rheumatol. Published 10 February 2024. doi:10.
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