Lupus & antiphospholipid syndrome
Time to diagnosis in systemic lupus erythematosus: Associated factors and its impact on damage accrual and mortality. Data from a multi-ethnic, multinational Latin American lupus cohort
Main finding · Damage accrualResult — go to the resultHazard ratio 1.09 95% CI 0.93–1.28Authors' conclusion
In this inception cohort, a maximum time of 24 months with a median of 6 months to SLE diagnosis had no apparent negative impact on disease outcomes (damage accrual and mortality).
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) from a multi-ethnic, multinational Latin American inception cohort; centres with specialized lupus clinics
- Participants
- 1,437 patients
- Exposure
- Time to diagnosis >6 months vs shorter time to diagnosis
- Longer time to diagnosisn = 721
- Outcome
- Damage accrual and mortality
Methodological detailsmulti-ethnic, multinational, multivariable Cox regression
- Multi-ethnic
- Multinational
- Multivariable Cox regression
Main finding
Damage accrual
Hazard ratio
1.09
95% CI 0.93–1.28
P = 0.300
Longer time to diagnosisvs Shorter time to diagnosis
HR 1.09 (95% CI 0.93–1.28); P = 0.300
As reported in the abstract
Observational data: associations, not effects.
Further findings
Characteristics associated with time to diagnosis >6 months
- More frequently female, older at diagnosis, of Mestizo ethnicity, without medical insurance, and with "non-classic" SLE symptoms
Time to SLE diagnosis
- Median time to diagnosis, months (Q1-Q3 2.4-16.2)
- 6.0
- Time to diagnosis longer than 6 months, n (%)
- 721 (50.2%)
Original publication
Time to diagnosis in systemic lupus erythematosus: Associated factors and its impact on damage accrual and mortality. Data from a multi-ethnic, multinational Latin American lupus cohort. Lupus. Published 9 February 2024. doi:10.
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