Lupus & antiphospholipid syndrome
Granulin in renal tubular epithelia is associated with interstitial inflammation and activates the TLR9-IFN-α pathway in lupus nephritis
Authors' conclusion
The expression of GRN in RTECs is associated with interstitial inflammation and therapeutic response. GRN may mediate the activation of the TLR9-IFN-α pathway in RTECs and involve in the micro-environment of inflammatory response in LN.
Study context
- Population
- Renal sections from lupus nephritis (LN) and non-LN patients; Granulin (GRN)-overexpressing renal tubular epithelial cells (RTECs)
- Participants
- 57 vs 30
- Comparison
- LN vs non-LN renal sections; GRN-overexpressing RTECs
- LNn = 57
- Non-LNn = 30reference
Methodological detailshistological study, cytological study
- Histological study
- Cytological study
Main finding
As reported in the abstract
- GRN highly expressed in LN RTECs with tubulointerstitial inflammation (TII) and well co-localized with TLR9
- ROC analysis suggested a potential relationship between GRN expression in RTECs and therapeutic response
- IFN-α highly expressed in LN RTECs with TII; IFN-α intensity positively correlated with GRN–TLR9 co-localization intensity
- LN serum, especially from LN with TII, activates TLR9 expression in RTECs
- GRN engages TLR9 to activate IFN-α expression in RTECs
- TLR9 inhibitors suppress IFN-α expression in RTECs, dose-dependently
Original publication
Granulin in renal tubular epithelia is associated with interstitial inflammation and activates the TLR9-IFN-α pathway in lupus nephritis. Lupus. Published 9 February 2024. doi:10.
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