Occurrence of comorbidity following osteoarthritis diagnosis: a cohort study in the Netherlands
Authors' conclusion
This study showed that many comorbidities were diagnosed more often in patients with knee or hip OA.
Study context
- Population
- Adults at risk for osteoarthritis (OA) in the Integrated Primary Care Information database (electronic health records), the Netherlands
- Participants
- 1,890,712 adults
- Exposure
- Exposed vs unexposed patient time
- Outcome
- Incidence of 58 long-term comorbidities (diagnostic codes, International Classification of Primary Care)
Methodological detailsexposed vs unexposed patient time, age and sex adjusted
- Exposed vs unexposed patient time
- Age and sex adjusted
Main finding
As reported in the abstract
Long-term comorbidities after knee or hip OA diagnosis (age- and sex-adjusted HR, exposed vs unexposed patient time)
- Knee OA: obesity, HR
- 2.55 (2.29-2.84) (99.9% CI)
- Knee OA: fibromyalgia, HR
- 2.06 (1.53-2.77) (99.9% CI)
- Knee OA: HR < 1 for two conditions; other comorbidities showed no association
- 2
- Hip OA: PMR, HR
- 1.81 (1.41-2.32) (99.9% CI)
- Hip OA: fibromyalgia, HR
- 1.70 (1.10-2.63) (99.9% CI)
Observational data: associations, not effects.
Original publication
Occurrence of comorbidity following osteoarthritis diagnosis: a cohort study in the Netherlands. Osteoarthritis Cartilage. Published 15 December 2022. doi:10.
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