Comorbidity in incident osteoarthritis cases and matched controls using electronic health record data
Authors' conclusion
Most of the comorbidities under study had higher odds in patients with incident OA at the index date. While previously known associations were confirmed in this study, some associations were not described earlier.
Study context
- Population
- Adults with newly diagnosed osteoarthritis (OA) in general practices throughout the Netherlands and matched controls without OA80,099 incident OA patients identified
- Participants
- 79,937 vs 318,206
- Comparison
- Incident OA cases vs matched controls without OA
- OAn = 79,937
- Controlsn = 318,206reference
- Outcome
- Prevalence of 58 previously diagnosed comorbidities (OR, cases vs matched controls)
- Follow-up
- Index date
Methodological detailsmatched (by age, sex and general practice) to up to 4 controls, electronic health record data
- Matched (by age, sex and general practice) to up to 4 controls
- Electronic health record data
Main finding
As reported in the abstract
Comorbidities with higher odds (of 58 studied)
- OA cases had higher odds for 42 of the 58 studied comorbidities vs matched controls
- Musculoskeletal diseases and obesity showed large associations with incident OA
Observational data: associations, not effects.
Original publication
Comorbidity in incident osteoarthritis cases and matched controls using electronic health record data. Arthritis Res Ther. Published 4 July 2023. doi:10.
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