Polyacrylamide gel versus hyaluronic acid for the treatment of knee osteoarthritis: a randomised controlled study
Primary result · WOMAC pain, least squares mean change from baselineResult — go to the resultGroup difference 3.7 95% CI −0.7 to 8.1Authors' conclusion
iPAAG was found to be as effective and safe as HA for treatment of knee OA symptoms for at least 1 year after a single injection.
Study context
- Population
- Adults with symptomatic and radiographic knee osteoarthritis (OA), 3 clinical rheumatology sites in Denmark
- Participants
- 239 adults
- Comparison
- Single intra-articular 6 mL injection of iPAAG vs hyaluronic acid (HA)
- iPAAGn = 119
- HAn = 120reference
- Primary endpoint
- Change from baseline in WOMAC pain subscale
- Follow-up
- 26 weeks
Methodological detailsnon-inferiority, multicentre
- Non-inferiority
- Multicentre
Primary result
As reported in the abstract
WOMAC pain, least squares mean change from baseline
Group difference
3.7
95% CI −0.7 to 8.1
Change by group
iPAAG
−18.5
least squares mean · 95% CI −21.7–-15.4
HA
−14.8
least squares mean · 95% CI −18.0–-11.7
HAvs iPAAG
group difference 3.7 (95% CI −0.7 to 8.1)
Non-inferiority margin 9 as printed, not drawn
Secondary outcomes
WOMAC stiffness and physical function, patients' global assessment, EuroQoL-5D-5L, OMERACT-OARSI responders · 26 and 52 weeks
- No statistically significant differences
Safety
Adverse device effects (participants reporting) · All ADEs mild/moderate; no serious ADEs
ADEs reported iPAAG 41 · HA 13
Original publication
Polyacrylamide gel versus hyaluronic acid for the treatment of knee osteoarthritis: a randomised controlled study. Clin Exp Rheumatol. Published 4 July 2023. doi:10.
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