Rheumatoid arthritis

Two‐Year Follow‐Up of a Multidisciplinary Lifestyle Intervention for Rheumatoid Arthritis and Osteoarthritis

Arthritis Care Res (Hoboken)Published Observational extension study of two randomised controlled trials

Authors' conclusion

Two years after the PFJ intervention, improvements in RA disease activity, MSOA symptoms and functioning, and intervention adherence were sustained.

Study context

Population
People with rheumatoid arthritis (RA) or metabolic syndrome-associated hip or knee OA after the Plants for Joints intervention (whole-food plant-based diet, exercise, stress reduction)48 RA and 44 MSOA completed
Participants
77 vs 64
Comparison
Two years after the Plants for Joints (PFJ) intervention vs start and end of intervention
  • RAn = 77
  • MSOAn = 64
Primary endpoint
DAS28 (RA) and WOMAC (MSOA)
Follow-up
Two years after intervention
Methodological detailstwo-year follow-up, linear mixed models, within-group comparisons
  • Two-year follow-up
  • Linear mixed models
  • Within-group comparisons

Primary result

As reported in the abstract

Within-group change vs start intervention
Estimate (95% CI)
RA
DAS28 change vs start intervention −0.9 points(−1.2 to −0.6)
MSOA
WOMAC change vs start intervention −8.8 points(−12.6 to −5.1)

Secondary outcomes

Secondary outcomes vs start intervention · two years after intervention

CRP significantly lower in RA
Weight, BMI, waist circumference and diastolic blood pressure significantly lower in MSOA
Medication use decreased slightly; participants continued to follow intervention recommendations

Original publication

Two‐Year Follow‐Up of a Multidisciplinary Lifestyle Intervention for Rheumatoid Arthritis and Osteoarthritis. Arthritis Care Res (Hoboken). Published 20 April 2025. doi:10.1002/acr.25553

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