Development of a prediction model for progression of rheumatoid arthritis-associated interstitial lung disease using serologic and clinical factors: The prospective Korean RA-ILD (KORAIL) cohort
Authors' conclusion
In this prospective cohort, UIP pattern, ILD extent, lower DLCO, RA disease activity, anti-CCP levels, and pulmonary damage biomarkers were associated with RA-ILD progression.
Study context
- Population
- Patients with RA meeting ACR/EULAR criteria and ILD on chest computed tomography (CT), Korean RA-ILD (KORAIL) cohort, followed for 3 yearsRA-ILD patients analysed
- Participants
- 138 patients
- Exposure
- Models without KL-6 vs Models with KL-6
- Outcome
- RA-ILD progression: both physiological and radiological worsening (adapted from 2023 ATS/ERS/JRS/ALAT progressive pulmonary fibrosis definition)
Methodological detailsprediction model development
- Prediction model development
Main finding
As reported in the abstract
RA-ILD progression · median follow-up 2.9 years
| Group | AUC |
|---|---|
| Models without KL-6 | 0.73 |
| Models with KL-6 | 0.75 |
AUC
Models without KL-60.73
Models with KL-60.75
%
- RA-ILD progression
- 34.8 (n = 48)
- PPV for progression, high-risk group
- 85.7
- NPV, low-risk group
- 94.7
Observational data: associations, not effects.
Original publication
Development of a prediction model for progression of rheumatoid arthritis-associated interstitial lung disease using serologic and clinical factors: The prospective KORAIL cohort. Semin Arthritis Rheum. Published 17 April 2025. doi:10.
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