Clinical and radiological distinctiveness of anti-cyclic citrullinated peptide antibody-negative rheumatoid arthritis-associated interstitial lung disease: a retrospective cohort study
Authors' conclusion
While anti-CCP-negative and anti-CCP-positive RA-ILD patients share many clinical similarities, the anti-CCP-negative subgroup is characterized by a distinct profile including lower frequencies of males and smoking, higher anti-SSB antibody positivity, and less severe fibrotic lesions on HRCT.
Study context
- Population
- RA-ILD patients admitted to Peking University Third Hospital, December 2009 to May 2025
- Participants
- 214 patients
- Exposure
- Anti-CCP-negative vs anti-CCP-positive RA-ILD
- Anti-CCP negativen = 41
- Anti-CCP positiven = 173reference
- Outcome
- Clinical, serological and HRCT differences
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Males: anti-CCP negative 17.1% vs anti-CCP positive 36.4%
- p < 0.05
- Smokers: anti-CCP negative 12.2% vs anti-CCP positive 28.3%
- p < 0.05
- Anti-SSB antibody positivity: anti-CCP negative 10.8% vs anti-CCP positive 2.5%
- p < 0.05
- High-resolution computed tomography (HRCT) fibrotic features (reticulation, honeycombing, traction bronchiectasis): anti-CCP negative 36.6% vs anti-CCP positive 67.1%
- p < 0.05
- Usual interstitial pneumonia pattern: anti-CCP negative 22.0% vs anti-CCP positive 43.4%
- p < 0.05
Observational data: associations, not effects.
Original publication
Clinical and radiological distinctiveness of anti-cyclic citrullinated peptide antibody-negative rheumatoid arthritis-associated interstitial lung disease: a retrospective cohort study. Scand J Rheumatol. Published 17 April 2026. doi:10.
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