A multidisciplinary lifestyle program for rheumatoid arthritis: the ‘Plants for Joints’ randomized controlled trial
Primary result · Improvement of DAS28Result — go to the resultMean difference (greater improvement) 0.9 point 95% CI 0.4–1.3Authors' conclusion
The 16-week PFJ multidisciplinary lifestyle program substantially decreased disease activity and improved metabolic status in people with RA with low-moderate disease activity.
Study context
- Population
- Patients with RA with low-moderate disease activity (DAS (DAS28) ≥2.6 and ≤5.1); 92% female, mean age 55 years77 completed
- Participants
- 83 patients
- Comparison
- 16-week multidisciplinary lifestyle program vs usual care
- Primary endpoint
- Disease activity (DAS28)
- Follow-up
- 16 weeks
Methodological detailsparallel-arm, assessor-blind, Medication kept stable 3 months before and during the trial whenever possible
- Parallel-arm
- Assessor-blind
- Medication kept stable 3 months before and during the trial whenever possible
Primary result
Improvement of DAS28
Mean difference (greater improvement)
0.9 point
95% CI 0.4–1.3
P < 0.0001
PFJvs Control
mean difference (greater improvement) 0.9 point (95% CI 0.4–1.3); P < 0.0001
As reported in the abstract
Secondary outcomes
| Outcome | Estimate |
|---|---|
| Anthropometric and metabolic measures (greater decreases with PFJ) · 16 weeksPFJ vs Control | difference (body weight) −3.9 kg |
| Anthropometric and metabolic measures (greater decreases with PFJ) · 16 weeksPFJ vs Control | difference (fat mass) −2.8 kg |
| Anthropometric and metabolic measures (greater decreases with PFJ) · 16 weeksPFJ vs Control | difference (waist circumference) −3 cm |
| Anthropometric and metabolic measures (greater decreases with PFJ) · 16 weeksPFJ vs Control | difference (HbA1c) −1.3 mmol/mol |
| Anthropometric and metabolic measures (greater decreases with PFJ) · 16 weeksPFJ vs Control | difference (LDL) −0.32 mmol/l |
Patient-reported outcomes, blood pressure, glucose and other lipids · 16 weeks
- Did not change
Original publication
A multidisciplinary lifestyle program for rheumatoid arthritis: the ‘Plants for Joints’ randomized controlled trial. Rheumatology (Oxford). Published 6 January 2023. doi:10.
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