Humoral responses against high-density lipoproteins (HDL) are linked to lipoprotein traits, atherosclerosis, inflammation and pathogenic pathways during early arthritis stages
Authors' conclusion
Humoral responses against HDL particles are an early event along the arthritis course, although quantitative and qualitative differences can be noticed among stages.
Study context
- Population
- Early RA patients, arthralgia individuals and controls; established RA for validation
- Participants
- 82 / 14 / 96 / 42
- Exposure
- Early RA and arthralgia vs controls
- Early RAn = 82
- Arthralgian = 14
- Controlsn = 96reference
- Established RAn = 42
- Outcome
- IgG and IgM serum anti-HDL and anti-ApoA1 antibody levels
Methodological detailsvalidation cohort of established RA
- Validation cohort of established RA
Main finding
As reported in the abstract
- Only anti-ApoA1 antibodies were increased in arthralgia
- Early RA vs Controls: both P < 0.001
Observational data: associations, not effects.
Further findings
- IgG anti-HDL and anti-ApoA1 associated with unfavourable lipoprotein traits in RA and arthralgia, respectively; similar for inflammatory mediators
- No associations with clinical features or risk factors
- IgG anti-HDL independently associated with atherosclerosis in early RA; outperformed mSCORE and anti-ApoA1 for stratification
- Anti-HDL correlated with proteins of immune activation, remodelling and lipid metabolism pathways in early RA
Original publication
Humoral responses against HDL are linked to lipoprotein traits, atherosclerosis, inflammation and pathogenic pathways during early arthritis stages. Rheumatology (Oxford). Published 6 January 2023. doi:10.
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