Long-term effectiveness of a lifestyle intervention for rheumatoid arthritis and osteoarthritis: 1-year follow-up of the ‘Plants for Joints’ randomised clinical trial
Authors' conclusion
A year after the PFJ lifestyle intervention, improvements of disease activity and metabolic outcomes within RA and MSOA groups were largely sustained and related to sustained adherence, with a net decrease of medication.
Study context
- Population
- People with rheumatoid arthritis (RA) or metabolic syndrome-associated hip or knee OA after two 16-week Plants for Joints (PFJ) trials65 of 77 RA and 49 of 64 MSOA completed
- Participants
- 77 vs 64
- Comparison
- Within-group changes after the PFJ multidisciplinary lifestyle intervention, 1 year after completion
- RAn = 77
- MSOAn = 64
- Primary endpoint
- DAS28 (RA) and WOMAC (MSOA)
- Follow-up
- 1 year after intervention completion
Methodological details1-year follow-up, control groups switched to active intervention, intention-to-treat, linear mixed model
- 1-year follow-up
- Control groups switched to active intervention
- Intention-to-treat
- Linear mixed model
Primary result
As reported in the abstract
a year after intervention completion
RA
−0.9
mean · points
MSOA
−7.8
points
- RA: mean Disease Activity Score (DAS28) change, p<0.001
- −0.9
- MSOA: WOMAC increased towards but remained well under the starting value, p<0.001
- −7.8
Secondary outcomes
CRP, waist circumference (RA and MSOA); LDL cholesterol (RA); weight, haemoglobin A1c, blood pressure (MSOA)
- Improvements sustained
Medication and adherence
- Net decrease of medication; adherence largely sustained
Original publication
Long-term effectiveness of a lifestyle intervention for rheumatoid arthritis and osteoarthritis: 1-year follow-up of the ‘Plants for Joints’ randomised clinical trial. RMD Open. Published 27 February 2024. doi:10.
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