Lupus & antiphospholipid syndrome
Objective and subjective sleep assessment in systemic lupus erythematosus and association with disease characteristics and quality of life
Authors' conclusion
Worse sleep quality was reported in SLE patients by both subjective and objective measures.
Study context
- Population
- Systemic lupus erythematosus (SLE) cases (mean age 37.11 years, 90% female) and matched healthy controls
- Participants
- 90 vs 90
- Comparison
- SLE cases vs matched healthy controls
- SLEn = 90
- Controlsn = 90reference
- Outcome
- Sleep quality by subjective (PSQI, ESS) and objective (Withings Sleep Analyzer) measures
Methodological detailsmatched healthy controls
- Matched healthy controls
Main finding
As reported in the abstract
Poor sleep (PSQI > 4)
| Group | Value | Mean Pittsburgh Sleep Quality Index (PSQI) (SD) |
|---|---|---|
| SLE | 82.2% | 7.59 (3.33) |
| Controls | 46.7% | 4.52 (2.90) |
Value
SLE82.2%
Controls46.7%
Mean Pittsburgh Sleep Quality Index (PSQI) (SD)
SLE7.59 (3.33)
Controls4.52 (2.90)
- SLE vs Controls: P < 0.01
Observational data: associations, not effects.
Further findings
Poor sleep by WSA (WSA score ≤ 65); 35 SLE cases and 50 controls assessed
P < 0.01
Associations of sleep scores (logistic regression)
- Higher PSQI associated with Epworth Sleepiness Scale (ESS)
- P < 0.01
- Higher PSQI associated with physical domain of WHO-QoL
- P < 0.01
- Withings Sleep Analyzer (WSA) scores correlated with physical domain of WHO-QoL
- P = 0.02
Original publication
Objective and subjective sleep assessment in systemic lupus erythematosus and association with disease characteristics and quality of life. Rheumatology (Oxford). Published 16 February 2026. doi:10.
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