Lupus & antiphospholipid syndrome
Diagnostic accuracy of the Arabic composite autonomic symptom score 31 (COMPASS-31) for detecting autonomic neuropathy in SLE: a cross-sectional validation study
Authors' conclusion
The Arabic COMPASS-31 demonstrates good discrimination for objectively confirmed autonomic neuropathy in SLE, with the orthostatic intolerance and pupillomotor domains contributing most of its discriminative value.
Study context
- Population
- Patients with SLE completing the Arabic COMPASS-31 before cardiovascular autonomic reflex testing (CART) and sympathetic skin response (SSR)
- Participants
- 45 / 23 / 45
- Comparison
- Arabic COMPASS-31 vs objective autonomic testing
- SLEn = 45
- Positive-controln = 23
- Healthy controlsn = 45reference
- Outcome
- Diagnostic accuracy of total COMPASS-31 score for objective autonomic neuropathy (abnormal CART and/or absent SSR) in SLE
Methodological detailscross-sectional, validation study
- Cross-sectional
- Validation study
Performance
As reported in the abstract
Discrimination of objective autonomic neuropathy (abnormal CART and/or absent SSR) by total COMPASS-31 score, within the SLE cohort
| Test or model | AUC | 95% CI | Cut-off | Sensitivity | Specificity |
|---|---|---|---|---|---|
| COMPASS-31 | 0.81 | 0.68 to 0.94 | ≥5 | 89% | 59% |
COMPASS-31
AUC0.81
95% CI0.68 to 0.94
Cut-off≥5
Sensitivity89%
Specificity59%
Further findings
Independent association of COMPASS-31 total score with autonomic neuropathy (adjusted for age, disease duration and disease activity)
| aOR (95% CI) | ||
|---|---|---|
| COMPASS-31 total score | 1.29 (1.06–1.57) | |
| 0.512Adjusted odds ratio (log scale) |
| Outcome | Values | P value |
|---|---|---|
| Discrimination of definite/severe autonomic neuropathy by total COMPASS-31 score | COMPASS-31 AUC 0.89 · 95% CI 0.79 to 0.98 | |
| Discrimination of autonomic neuropathy by COMPASS-31 domainsOrthostatic intolerance and pupillomotor domains vs COMPASS-31 total score · performed similarly | Orthostatic intolerance AUC 0.78 · 95% CI 0.64 to 0.91 · Pupillomotor AUC 0.77 · 95% CI 0.64 to 0.90 | DeLong's test, both p>0.4 |
Discrimination of autonomic neuropathy by COMPASS-31 domains
- Vasomotor, secretomotor, gastrointestinal and bladder domains performed significantly worse than the total score
Internal consistency of the Arabic COMPASS-31
- Cronbach's α
- 0.83
- McDonald's ω
- 0.857
- Good
Original publication
Diagnostic accuracy of the Arabic composite autonomic symptom score 31 (COMPASS-31) for detecting autonomic neuropathy in SLE: a cross-sectional validation study. Lupus Sci Med. Published 29 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →