Lupus & antiphospholipid syndrome
Protein biomarkers of inflammation in women with SLE and their newborn children
Authors' conclusion
Women with SLE and their newborn children had increased expression of a range of proinflammatory biomarkers irrespective of their anti-SSA/SSB or anti-dsDNA autoantibody status.
Study context
- Population
- Pregnant women with SLE and healthy pregnant women, along with their newbornsmother-child pairs
- Participants
- 22 vs 22
- Exposure
- Women with SLE and their newborns vs healthy pregnant women and their newborns
- SLEn = 22
- Healthy controlsn = 22reference
- Outcome
- IFN activation and expression of other immune-related proteins in mothers and newborns
Methodological detailsproximity extension assay (92 immune-related proteins)
- Proximity extension assay (92 immune-related proteins)
Main finding
As reported in the abstract
Immune-related protein expression (92 proteins)
Differential expression in women with SLE vs healthy controls (proteins)
39 out of 92
Observational data: associations, not effects.
Original publication
Protein biomarkers of inflammation in women with SLE and their newborn children. Lupus Sci Med. Published 29 September 2026. doi:10.
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