Vasculitis & polymyalgia rheumatica
Non-invasive biomarkers of disease activity and organ damage in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis: a systematic review
Authors' conclusion
This is the first contemporary systematic review synthesising the value of non-invasive biomarkers of AAV-related disease activity and organ damage.
Study context
- Population
- Patients with AAV; studies of non-invasive (blood-based or urinary) biomarkers of disease activity and organ damage, 2012 until present22 high quality studies
- Outcome
- Non-invasive biomarkers of AAV disease activity and/or organ damage
Methodological detailsdescriptive synthesis, quality assessed with STROBE, RoBANS or Cochrane RoB 2.0
- Descriptive synthesis
- Quality assessed with STROBE, RoBANS or Cochrane RoB 2.0
Pooled result
As reported in the abstract
- Biomarkers reported include ANCA, immune cells, complement factors, gene expression profiles, cytokines, chemokines and other proteins
- Many of these biomarkers involve the alternative complement pathway, neutrophil activation and macrophage activation
Original publication
Non-invasive biomarkers of disease activity and organ damage in ANCA-associated vasculitis: a systematic review. RMD Open. Published 9 February 2024. doi:10.
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