Vasculitis & polymyalgia rheumatica
Serum protein profiling reveals distinct patient clusters in giant cell arteritis
Authors' conclusion
Protein profiling identified patient clusters in GCA with distinct proteomic features and therefore likely different pathophysiology.
Study context
- Population
- Patients with GCA, new-onset and in remission; 1463 serum proteins analysed
- Participants
- 16 vs 13
- Comparison
- New-onset GCA vs Remission
- New-onset GCAn = 16
- Remissionn = 13
- Outcome
- Serum protein clusters
Methodological detailsproximity extension assays, unsupervised and supervised cluster analyses
- Proximity extension assays
- Unsupervised and supervised cluster analyses
Main finding
As reported in the abstract
- Unsupervised cluster analysis identified three distinct clusters based on the protein signature
- 3
Original publication
Serum protein profiling reveals distinct patient clusters in giant cell arteritis. Rheumatology (Oxford). Published 7 February 2024. doi:10.
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