Vasculitis & polymyalgia rheumatica
Reappraisal of large artery involvement in giant cell arteritis: a population-based cohort over 70 years
Main finding · Cumulative incidence of LA involvement in GCAResult — go to the resultHazard ratio 3.48 95% CI 1.67–7.27Authors' conclusion
LA involvement in GCA has increased over time. Patients with GCA have higher incidences of LA involvement compared with non-GCA including thoracic but not abdominal aneurysms. Mortality is increased in patients with GCA and LA involvement
Study context
- Population
- Olmsted County, Minnesota, USA residents with incident giant cell arteritis (GCA) 1950–2016, follow-up through 31 December 2020 (77% females, 81% temporal artery biopsy positive)106 with large artery (LA) involvement
- Participants
- 289 participants
- Exposure
- GCA vs age- and sex-matched non-GCA comparators; GCA incidence periods 1950-1974, 1975-1999, 2000-2016
- GCAn = 289
- Outcome
- LA involvement (aortic aneurysm, dissection, stenosis in the aorta or its main branches) diagnosed within 1 year prior to GCA or anytime afterwards
- Follow-up
- 15 years
Methodological detailspopulation-based, age-matched/sex-matched comparator cohort, Cox models
- Population-based
- Age-matched/sex-matched comparator cohort
- Cox models
Main finding
Cumulative incidence of LA involvement in GCA
Hazard ratio
3.48
95% CI 1.67–7.27
By group
2000-2016vs 1950-1974
HR 3.48 (95% CI 1.67–7.27)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| LA involvement, GCAvs non-GCAAdjusted for age, sex, comorbidities | 3.22 (1.83–5.68) | |
| Thoracic aortic aneurysmGCAvs Non-GCA | 13.46 (1.78–101.98) | |
| Abdominal aortic aneurysmGCAvs Non-GCA | 1.08 (0.33–3.55) | |
| All-cause mortality in GCA, by period2000-2016vs 1950-1974 | 0.62 (0.41–0.93) | |
| 0.050.21520Hazard ratio (log scale) |
All-cause mortality in GCA with vs without LA involvement
| HR (95% CI) | ||
|---|---|---|
| GCA with LA involvement | 1.89 (1.39–2.56) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Reappraisal of large artery involvement in giant cell arteritis: a population-based cohort over 70 years. RMD Open. Published 8 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →