Vasculitis & polymyalgia rheumatica
Lower Frequency of Comorbidities Prior to Onset of Giant Cell Arteritis: A Population-Based Study
Authors' conclusion
DM prevalence and median FBG and BMI were lower in patients with GCA up to 5 years prior to diagnosis, suggesting that metabolic factors influence the risk of GCA.
Study context
- Population
- Patients with incident giant cell arteritis (GCA) between January 1, 2000, and December 31, 2019, in Olmsted County, Minnesota, and matched controls74% of GCA female
- Participants
- 129 vs 253
- Comparison
- Incident GCA vs age- and sex-matched controls
- GCAn = 129
- Controlsn = 253reference
- Outcome
- Frequency of comorbidities and metabolic risk factors at and prior to GCA diagnosis
- Follow-up
- Incidence date, 5 and 10 years prior
Methodological detailspopulation-based, age- and sex-matched controls (2 per case), multivariable logistic regression
- Population-based
- Age- and sex-matched controls (2 per case)
- Multivariable logistic regression
Main finding
As reported in the abstract
Prevalence of diabetes mellitus (DM) · incidence date
P = 0.001
Observational data: associations, not effects.
Further findings
DM · 5 years prior to incidence date
P < 0.001
Hypertension · 5 years prior to incidence date
P = 0.002
Fasting blood glucose · 5 years prior to incidence date
P < 0.001
| Outcome | GCA | Controls | P value |
|---|---|---|---|
| Number of comorbidities · 5 years prior to incidence dateMean | 0.7 (SD 1.0) | 1.3 (SD 1.4) | P < 0.001 |
| BMI · 5 years prior to incidence dateMedian | 25.8 | 27.7 | P = 0.02 |
Fasting blood glucose (FBG) and GCA, multivariable logistic regression · 5 and 10 years prior to diagnosis/index date
- Negative associations for FBG with GCA
Original publication
Lower Frequency of Comorbidities Prior to Onset of Giant Cell Arteritis: A Population-Based Study. J Rheumatol. Published 15 December 2022. doi:10.
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