Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus: A multicenter study
Authors' conclusion
We detected the prevalence of juvenile NPSLE manifestations in Turkey.
Study context
- Population
- Turkish patients with juvenile-onset SLE (jSLE) from 24 referral centres' SLE cohorts
- Participants
- 1,107 patients
- Outcome
- Prevalence of neuropsychiatric involvement in jSLE
Methodological detailsmultidisciplinary network, 24 referral centres, Ward's hierarchical clustering, univariate and multivariate logistic regression
- Multidisciplinary network
- 24 referral centres
- Ward's hierarchical clustering
- Univariate and multivariate logistic regression
Main finding
As reported in the abstract
NP involvement (prevalence)
jSLE patients with neuropsychiatric (NP) involvement
149
13.5%
Observational data: associations, not effects.
Further findings
Most common NPSLE findings
- Headache
- 50.3%
- Seizure
- 38.3%
- Acute confusional state
- 33.6%
Clusters of clinical and laboratory findings
- Clusters identified
- 5
Risk factors for neurologic sequelae (multivariate analysis)
- APA positivity, OR (%95CI 1.002-7.939), P: 0,050
- 2.820
- Plasmapheresis, OR (%95CI 2.785-68.432), P: 0,001
- 13.804
- SLEDAI scores, OR (%95CI 1.049-1.186), P: 0,001
- 1.115
- Associated with increased risk for neurologic sequelae
Original publication
Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus: A multicenter study. Joint Bone Spine. Published 28 February 2023. doi:10.
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