Adipokine profile in long-term juvenile dermatomyositis, and associations with adipose tissue distribution and cardiac function: a cross-sectional study
Authors' conclusion
After long-term disease, leptin levels were unfavourably regulated in patients with JDM compared with controls, and apelin-12 and visfatin in JDM-active versus JDM-inactive. We found associations between adipokines and both adipose tissue distribution and cardiac systolic function in all patients with JDM, which was most prominent in patients with active disease.
Study context
- Population
- Patients with long-term juvenile dermatomyositis (JDM) (60% female, mean age 25.2 years, mean disease duration 16.9 years) and age/sex-matched controlsmatched cohort
- Exposure
- JDM vs age/sex-matched controls; JDM-active vs JDM-inactive
- JDMn = 59
- Controlsn = 59reference
- Outcome
- Serum adipokine levels (adiponectin, apelin-12, lipocalin-2, leptin, visfatin, resistin) in JDM vs controls
Methodological detailsage/sex-matched controls
- Age/sex-matched controls
Main finding
As reported in the abstract
Serum adipokines
- Higher leptin in JDM vs controls
- Higher apelin-12 and visfatin in JDM-active vs JDM-inactive
- JDM vs Controls: P ≤ 0.01
- JDM-active vs JDM-inactive: P ≤ 0.05
Observational data: associations, not effects.
Further findings
Adipokines and adipose tissue distribution
- In JDM-total and JDM-active, lower adiponectin correlated with lipodystrophy and total fat mass
Adipokines and systolic dysfunction
- Systolic dysfunction correlated with lower adiponectin in JDM-total, JDM-inactive and JDM-active; with lower apelin-12 in JDM-total and JDM-active; and with resistin in JDM-active
- all p≤0.05
Adipokines and diastolic dysfunction
- Lower adiponectin correlated with diastolic dysfunction in JDM-total and JDM-active
Original publication
Adipokine profile in long-term juvenile dermatomyositis, and associations with adipose tissue distribution and cardiac function: a cross-sectional study. RMD Open. Published 24 February 2023. doi:10.
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