Vasculitis & polymyalgia rheumatica
Neutrophil extracellular traps (NETs) in the spotlight: exploring NETosis markers for tracking disease activity in IgA vasculitis
Authors' conclusion
Elevated serum cf-DNA and urine cit-H3 suggest a potential role for NETosis in IgAV activity, highlighting these markers as potential indicators for disease monitoring.
Study context
- Population
- Paediatric IgA vasculitis (IgAV) patients and healthy controls33 patients · 26 controls
- Exposure
- Paediatric IgAV patients in active and inactive disease phases vs healthy controls
- Healthy controlsn = 26reference
- Outcome
- NETosis markers (cell-free DNA (cf-DNA), neutrophil elastase, MPO, cit-H3) in blood and urine across IgAV disease phases
Main finding
As reported in the abstract
NETosis markers
- Active vs Controls: P = 0.04
- Active vs Inactive: P = 0.04
- Active vs Controls: P = 0.009
- Active vs Controls: P = 0.01
- Inactive vs Controls: P = 0.03
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Serum cf-DNA threshold 935 ng/ml for active disease | cf-DNA 935 ng/ml sensitivity 93% · specificity 72% |
Gender and age, patients vs controls
- No significant difference
Original publication
NETs in the spotlight: exploring NETosis markers for tracking disease activity in IgA vasculitis. Rheumatology (Oxford). Published 21 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →