Vasculitis & polymyalgia rheumatica

Treatment strategies and outcomes in adult relapsing or refractory cutaneous IgA Vasculitis: A multicenter retrospective cohort study

Semin Arthritis RheumPublished Retrospective cohort study

Authors' conclusion

In adult relapsing or refractory cutaneous IgA vasculitis, dapsone, GCs and cDMARDs provided the highest rates of cutaneous response.

Study context

Population
Adults with IgAV with cutaneous relapses or refractory disease after first-line therapy, France64% male
Participants
52 adults
Exposure
Second-line treatment regimens after failure of first-line therapy
Outcome
Rate of cutaneous response
Follow-up
Month 3
Methodological detailsmulticentre
  • Multicentre

Main finding

As reported in the abstract

Cutaneous response · 3 months

Observational data: associations, not effects.

Further findings

Relapse rate

Additional lines of treatment after first-line failure

Median additional lines of treatment [1-2.3]
1
  • First-line: colchicine 54%, low-dose glucocorticoids (GCs) 38%

Original publication

Treatment strategies and outcomes in adult relapsing or refractory cutaneous IgA Vasculitis: A multicenter retrospective cohort study. Semin Arthritis Rheum. Published 6 November 2025. doi:10.1016/j.semarthrit.2025.152870

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