Systemic sclerosis & Raynaud's
Muscle involvement in systemic sclerosis: high mortality not associated with nature of histological lesions
Authors' conclusion
The mortality rate in scleroderma patients with muscle involvement was not associated with their histological patterns.
Study context
- Population
- Patients with SSc and histologically proven muscle involvement who had undergone muscle biopsy21 died during follow-up
- Participants
- 71 patients
- Exposure
- Fibrosing myopathy vs inflammatory myopathy vs immune-mediated necrotizing myopathy
- Fibrosing myopathy (FMy)n = 33
- Inflammatory myopathy (IMy)n = 18
- Immune-mediated necrotizing myopathy (IMNMy)n = 20
- Outcome
- Survival (association of histological patterns with prognosis)
Methodological detailsmulticentre, coordinated review of muscle biopsies
- Multicentre
- Coordinated review of muscle biopsies
Main finding
As reported in the abstract
Survival · 10 years after first non-RP symptom
10-year survival rate after first non-RP symptom
80%
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Pulmonary eventsIMyvs FMy | 0.17 (0.04–0.67) | |
| Pulmonary eventsIMyvs IMNMy | 0.28 (0.06–1.24) | |
| 0.050.21520Hazard ratio (log scale) |
Cumulative incidence of muscle relapse
- Cumulative incidence of muscle relapse
- 25%
- Did not differ significantly between the three groups
Cardiac events
- Did not differ significantly between the three groups
Original publication
Muscle involvement in systemic sclerosis: high mortality not associated with nature of histological lesions. Rheumatology (Oxford). Published 13 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →