Monocyte STAT1 phosphorylation and treatment response of janus kinase (JAK) inhibitors in chronic nonbacterial osteomyelitis
Authors' conclusion
The monocyte pSTAT1 levels after IFNγ stimulation reflect the activity of CNO, indicating the diagnostic utility as well as the monitoring effect of disease control. Adjunctive JAK inhibitors successfully controlled inflammation in treatment-resistant cases.
Study context
- Population
- Patients under 15 years old with chronic nonbacterial osteomyelitis (CNO); 4 with intractable CNO treated with adjunctive JAKi
- Comparison
- Monocyte pSTAT1 after IFNγ stimulation in CNO vs STAT1-gain of function (STAT1-GOF), other autoinflammatory diseases and healthy controls; before vs after adjunctive JAKi in intractable CNO
- CNOn = 9
- STAT1-GOFn = 5
- Other autoinflammatory diseasesn = 7reference
- Outcome
- Monocyte pSTAT1 expression after IFNγ stimulation
Methodological detailsflow cytometry, longitudinal monitoring
- Flow cytometry
- Longitudinal monitoring
Main finding
As reported in the abstract
- Decreased in 5 patients during clinical remission after conventional therapies
- p = 0.016
- In 4 intractable cases, remained high despite conventional treatment but significantly decreased after initiating JAKi
- p = 0.036
Further findings
Correlation of pSTAT1 reduction on JAKi with clinical improvement (4 intractable cases)
- Improved patient pain VAS
- P = 0.008
- Improved CNO clinical disease activity score
- P = 0.029
- Better bone and joint imaging; cytokine levels unchanged
Original publication
Monocyte STAT1 phosphorylation and treatment response of JAK inhibitors in chronic nonbacterial osteomyelitis. Pediatr Rheumatol Online J. Published 23 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →