Moderate-intensity exercise reduces osteoporotic fracture risk in older women: a dose-response analysis from a nationwide Korean cohort
Authors' conclusion
Our findings suggest that moderate-intensity exercise (3-5 days/week) appears optimal for reducing fracture risk, while excessive vigorous activity should be approached with caution, especially for older women with compromised BMD.
Study context
- Population
- Women aged 66 years, Korean National Health Insurance Service (NHIS) database; Bone mineral density (BMD) classified as normal, osteopenia or osteoporosis; mean follow-up 7.3 yearswomen aged 66 years
- Participants
- 541,770 women
- Exposure
- Physical activity patterns and fracture risk
- Outcome
- Osteoporotic fracture risk (vertebral and hip fractures)
Methodological detailsnationwide, Cox proportional hazards models, adjusted for demographic and clinical covariates
- Nationwide
- Cox proportional hazards models
- Adjusted for demographic and clinical covariates
Main finding
As reported in the abstract
Hazard ratio (95% CI)
Vigorous activity ≥ 6 days/weekhip fracture, osteoporosis participants
1.241(1.010–1.525)
MET Q4vs MET Q1osteopenia
0.939(0.910–0.970)
MET Q4vs MET Q1osteoporosis
0.894(0.866–0.922)
- Moderate-intensity exercise 3-5 days/week · vertebral fracture
- HR 0.862-0.891; all p < 0.001
- Moderate-intensity exercise 3-5 days/week · hip fracture
- HR 0.882-0.890; P < 0.02
Observational data: associations, not effects.
Original publication
Moderate-intensity exercise reduces osteoporotic fracture risk in older women: a dose-response analysis from a nationwide Korean cohort. Osteoporos Int. Published 1 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →