Impact of smoking, diabetes, and exercise on dementia risk in women with osteoporosis: a nationwide cohort study
Main finding · Dementia (adjusted for demographics and chronic comorbidities)Result — go to the resultHazard ratio 1.18Authors' conclusion
This population-based cohort study demonstrates that having osteoporosis significantly increases dementia risk, which is amplified by smoking and diabetes but reduced by regular exercise.
Study context
- Population
- Women aged 66 years in the National Screening Program for Transitional Ages for Koreans, first checkup January 2013–December 2016
- Participants
- 261,343 women
- Exposure
- Osteoporosis and osteopenia vs normal bone mineral density (BMD)
- Outcome
- Dementia
Methodological detailsnationwide, population-based
- Nationwide
- Population-based
Main finding
As reported in the abstract
Dementia (adjusted for demographics and chronic comorbidities)
Hazard ratio
1.18
Observational data: associations, not effects.
Further findings
| Outcome | Participants with osteoporosis who exercised regularly | Participants with osteoporosis who did not exercise | HR |
|---|---|---|---|
| Vascular dementiaOsteoporosis vs Normal BMD · reported as 1.25-fold higher risk | 1.25 | ||
| Dementia by osteoporosis and smokingParticipants with osteoporosis who smoked vs nonsmoking participants with normal BMD · 1.82-fold higher HR | 1.82 | ||
| Dementia by osteoporosis and DMParticipants with osteoporosis with DM vs participants with normal BMD without DM · 1.92-fold higher HR | 1.92 | ||
| Dementia by osteoporosis and regular exercise | |||
| HR | 1.00 | 1.18 |
Original publication
Impact of smoking, diabetes, and exercise on dementia risk in women with osteoporosis: a nationwide cohort study. Osteoporos Int. Published 10 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →