Vasculitis & polymyalgia rheumatica
Microbiome and Behçet's disease: a systematic review
Authors' conclusion
The microbiome may thus be involved in BD through immunity regulation and epigenetic modifications.
Study context
- Population
- Patients with Behçet's disease (BD); studies of the microbiota and the microbiome–immunity relationship in BD16 articles
- Outcome
- Changes in the microbiota of patients with BD and mechanisms linking the microbiome and immunity in BD
Methodological detailsqualitative synthesis, Search of PubMed and the Cochrane Library: "microbiota AND Behçet's disease" or "microbiome AND Behçet's disease"
- Qualitative synthesis
- Search of PubMed and the Cochrane Library: "microbiota AND Behçet's disease" or "microbiome AND Behçet's disease"
Pooled result
As reported in the abstract
Microbiota changes in BD
- Gut dysbiosis present in BD patients
- Decrease in butyrate-producing bacteria, which could affect T cell differentiation and epigenetic regulation of immune-related genes
- Modification of tryptophan-metabolising bacteria, possibly linked to dysregulated IL-22 secretion
- Decrease in bacteria known to have anti-inflammatory properties
- Oral microbiota: possible role of Streptococcus sanguinis through molecular mimicry and NETosis
Further pooled results
Clinical studies of BD
- Need for dentistry associated with a more severe course in BD
- Antibiotic-supplemented mouthwash reduces pain and ulcers
Animal models
- Fecal transplantation of BD patients' microbiota into mice led to decreased SCFA production, neutrophil activation, and Th1/Th17 responses
- Recipient mice showed exacerbated experimental autoimmune uveitis (EAU) and experimental autoimmune encephalomyelitis (EAE)
- In HSV-1 infected mice mimicking BD, butyrate-producing bacteria improved symptoms and immune variables
Original publication
Microbiome and Behçet's disease: a systematic review. Clin Exp Rheumatol. Published 16 September 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →