Vasculitis & polymyalgia rheumatica
Alterations of Gut Microbiome, Metabolome, and Lipidome in Takayasu Arteritis
Authors' conclusion
This study first identifies the discriminatory gut microbes in TAK. Dysbiotic microbes are also linked to TAK phenotypes directly or indirectly via metabolic and lipid modules.
Study context
- Population
- TAK patients, healthy controls and controls with Behçet's disease (BD); fecal metagenome, plasma and fecal metabolomics/lipidomicsdiscovery n = 97
- Comparison
- TAK patients vs healthy controls and BD controls
- Outcome
- Discrimination of TAK from controls by a combined model of gut bacterial species
Methodological detailsshotgun metagenomic sequencing, untargeted metabolomics and lipidomics, discovery and independent validation cohorts, external validation
- Shotgun metagenomic sequencing
- Untargeted metabolomics and lipidomics
- Discovery and independent validation cohorts
- External validation
Main finding
As reported in the abstract
Discrimination of TAK patients from controls by a combined model of gut bacterial species (shotgun fecal metagenome)
AUC, training set
87.8%
AUC, test set
85.9%
AUC, validation set including healthy controls
81.1%
AUC, validation set including BD controls
71.1%
Observational data: associations, not effects.
Further findings
Correlation of diagnostic species with TAK phenotypes
- Diagnostic species directly or indirectly (via metabolites or lipids) correlated with vascular involvement, inflammation, discharge medication and prognosis
External validation vs public metagenomic studies (hypertension, AF, healthy controls; n = 184)
- Diagnostic accuracy of the model for TAK confirmed
Original publication
Alterations of Gut Microbiome, Metabolome, and Lipidome in Takayasu Arteritis. Arthritis Rheumatol. Published 14 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →