Vasculitis & polymyalgia rheumatica
Integrative metabolomics of plasma and peripheral blood mononuclear cells (PBMCs) identifies distinctive metabolic signatures in Behçet’s disease
Authors' conclusion
We identified metabolic biomarkers from plasma PBMC, which selectively discriminated BD from healthy control and patients with similar symptoms (recurrent mouth ulcers with/without genital ulcers). The strong correlation was determined between the BD activity and the lipid molecules.
Study context
- Population
- Patients with behçet's disease (BD), healthy controls (HCs) and disease controls (DCs); plasma samples, plus PBMC lipid profiles (29 BD, 18 HCs, 19 DCs)66 PBMC samples
- Participants
- 40 / 18 / 17
- Comparison
- BD vs healthy controls and disease controls
- BDn = 40
- HCsn = 18reference
- DCsn = 17reference
- Outcome
- Diagnostic discrimination of BD from HC and DC
Methodological detailsuntargeted metabolomics, integrative metabolomic and lipidomic profiling, GC-TOF MS and LC-Orbitrap MS
- Untargeted metabolomics
- Integrative metabolomic and lipidomic profiling
- GC-TOF MS and LC-Orbitrap MS
Main finding
As reported in the abstract
Plasma biomarker panel (13 compounds) distinguishing BD from HC and DC, AUC range
0.810 to 0.966
Ten PBMC-derived lipid composites, AUC range
0.900 to 0.973
Observational data: associations, not effects.
Original publication
Integrative metabolomics of plasma and PBMCs identifies distinctive metabolic signatures in Behçet’s disease. Arthritis Res Ther. Published 7 January 2023. doi:10.
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