Vasculitis & polymyalgia rheumatica
Longitudinal Characterization of Vascular Inflammation and Disease Activity in Takayasu Arteritis and Giant Cell Arteritis: A Single‐Center Prospective Study
Authors' conclusion
Disease activity in GCA and TAK is common throughout the disease course. Patterns of vascular PET activity at diagnosis and later in disease differ between GCA and TAK.
Study context
- Population
- Patients with giant cell arteritis (GCA) or TAK enrolled at any point in the disease course, single-center prospective cohort
- Participants
- 126 patients319 visits
- Exposure
- GCA vs TAK
- GCAn = 50
- TAKn = 76
- Outcome
- Disease activity over time by multimodal assessment (clinical, laboratory, FDG-PET imaging; PETVAS)
Methodological detailssingle-centre, observational, longitudinal
- Single-centre
- Observational
- Longitudinal
Main finding
As reported in the abstract
Disease activity by disease duration (all patients)
Clinical disease activity, years 2–5 of disease
33%
Clinical disease activity, >5 years after diagnosis
24%
Active vasculitis by PET, years 2–5 after diagnosis
66%
Active vasculitis by PET, enrolled >5 years into disease
50%
Observational data: associations, not effects.
Further findings
Correlations between clinical, laboratory and imaging findings
- Complex and varied with disease duration
Original publication
Longitudinal Characterization of Vascular Inflammation and Disease Activity in Takayasu Arteritis and Giant Cell Arteritis: A Single‐Center Prospective Study. Arthritis Care Res (Hoboken). Published 5 January 2023. doi:10.
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