Vasculitis & polymyalgia rheumatica

The provisional OMERACT ultrasonography score for giant cell arteritis

Ann Rheum DisPublished Instrument development and validation study

Authors' conclusion

We developed a provisional OGUS for potential use in clinical trials.

Study context

Population
Patients with new giant cell arteritis (GCA) (prospective cohort); reliability images from 16 patients with GCA and 7 controls; OMERACT ultrasonography LVV working group membersprospective cohort
Participants
52 patients
Outcome
Metric properties of the OMERACT GCA Ultrasonography Score (OGUS)
Methodological detailsOMERACT Instrument Selection Algorithm, Delphi consensus (seven rounds), online reliability exercise, prospective cohort, intima-media thickness (IMT) measured at weeks 1, 3, 6, 12 and 24, 49 working group members invited to seven Delphi rounds; 35 conducted the reliability exercise
  • OMERACT Instrument Selection Algorithm
  • Delphi consensus (seven rounds)
  • Online reliability exercise
  • Prospective cohort
  • IMT measured at weeks 1, 3, 6, 12 and 24
  • 49 working group members invited to seven Delphi rounds; 35 conducted the reliability exercise

Performance

As reported in the abstract

Delphi agreement on OMERACT GCA Ultrasonography Score (OGUS)
92.7%
Interrater intraclass correlation coefficient (ICC) for OGUS
0.72-0.84
Median intrareader ICC
0.91
Sensitivity to change, baseline to each follow-up up to week 24 (SMD; large to very large)
−1.19 to −2.16
Correlation with ESR, CRP and BVAS (moderate)
0.37-0.48

Original publication

The provisional OMERACT ultrasonography score for giant cell arteritis. Ann Rheum Dis. Published 12 December 2022. doi:10.1136/ard-2022-223367

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