Vasculitis & polymyalgia rheumatica
The relationship between NETosis findings and disease activity in Behçet disease: an exploratory study
Authors' conclusion
Indirect NETosis findings varied in relation to the systemic and/or local activity of BD patients.
Study context
- Population
- Patients with Behçet disease (BD) in active and remission periods, and healthy controls
- Participants
- 30 vs 10
- Comparison
- Active and inactive BD vs healthy controls
- Active BDn = 30
- Controlsn = 10reference
- Primary endpoint
- Serum and saliva cf-DNA, NE, MPO and cit-H3 levels (indirect NETosis findings), unadjusted and adjusted for peripheral blood neutrophil counts, in relation to disease activity
Methodological detailslongitudinal follow-up of a subset
- Longitudinal follow-up of a subset
Primary result
As reported in the abstract
Indirect NETosis findings vs controls
- Active BD: unadjusted serum cf-DNA and NE significantly higher than controls; adjusted serum MPO and cit-H3 lower
- Inactive BD: unadjusted serum NE remained elevated vs controls; unadjusted serum MPO, adjusted serum MPO and adjusted serum cit-H3 lower
- Salivary NETosis findings: no significant differences between patients and controls
Further findings
Longitudinal follow-up and correlations with inflammatory markers
- Unadjusted serum cf-DNA and saliva cf-DNA decreased in parallel with reduced clinical activity
- Saliva and unadjusted serum cf-DNA correlated positively with inflammatory markers; adjusted serum MPO and cit-H3 correlated negatively
Original publication
The relationship between NETosis findings and disease activity in Behçet disease: an exploratory study. Clin Exp Rheumatol. Published 4 April 2025. doi:10.
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