Vasculitis & polymyalgia rheumatica
Comparative risk of blindness and vision-threatening ocular comorbidities in patients with Behçet’s disease versus the general population
Main finding · Blindness, incidence rate per 1000 person-yearsResult — go to the resultHazard ratio 10.73 95% CI 7.10–16.22Authors' conclusion
In this large population-based cohort study, BD patients compared with the general population have a 10.73-fold risk of blindness in 10 years and also a substantially higher risk of diverse ocular comorbidities that pose potential threats to vision.
Study context
- Population
- Korea National Health Insurance Service database, 2002–2017: newly diagnosed Behçet's disease (BD) patients and matched non-BD controlsfollow-up 9.39 years
- Participants
- 31,228 vs 156,140
- Exposure
- Newly diagnosed BD vs age- and sex-matched non-BD controls
- BDn = 31,228
- Controlsn = 156,140reference
- Outcome
- Blindness (best-corrected visual acuity ≤20/500 in the better-seeing eye)
Methodological detailsage- and sex-matched 1:5, Cox proportional hazards models
- Age- and sex-matched 1:5
- Cox proportional hazards models
Main finding
Blindness, incidence rate per 1000 person-years
Hazard ratio
10.73
95% CI 7.10–16.22
By group
BDvs Controls
HR 10.73 (95% CI 7.10–16.22)
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
Cataract surgery
- HR, BD vs controls
- 2.06 (95% CI 1.98, 2.15)
Glaucoma surgery
- HR, BD vs controls
- 5.43 (4.57, 6.45)
Retinal surgery
- HR, BD vs controls
- 2.71 (2.39, 3.07)
Incident uveitis
- HR, BD vs controls
- 6.19 (95% CI 5.83, 6.58)
Blindness by sex (subgroup)
- Males suffered a disproportionately higher risk of blindness than females due to greater severity rather than a lower incidence of uveitis
Uveitis and blindness by BD diagnosis age (subgroup)
- Risk of uveitis and blindness decreased as BD diagnosis age increased
Original publication
Comparative risk of blindness and vision-threatening ocular comorbidities in patients with Behçet’s disease versus the general population. Rheumatology (Oxford). Published 14 September 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →