Vasculitis & polymyalgia rheumatica
The predictive value of Berden's classification versus renal risk score for renal survival of Chinese patients with myeloperoxidase-anti-neutrophil cytoplasmic antibody-associated glomerulonephritis
Authors' conclusion
The model based on RRS has better predictive value for renal survival than Berden's classification in aspect of discrimination and clinical decision from 0.5- to 3-year renal survival.
Study context
- Population
- Chinese patients with MPO-ANCA-associated glomerulonephritis (MPO-AAGN) diagnosed in one centre, February 2004 to December 2020
- Participants
- 225 patients
- Exposure
- Berden's classification vs renal risk score (RRS) for predicting renal survival
- Outcome
- Prediction of renal survival (discrimination, calibration, decision curve analysis)
- Follow-up
- 0.5-, 1-, 3- and 5-year
Methodological detailssingle-centre, Cox regression, time-dependent ROC curve analysis, calibration analysis, decision curve analysis
- Single-centre
- Cox regression
- Time-dependent ROC curve analysis
- Calibration analysis
- Decision curve analysis
Main finding
As reported in the abstract
Prediction of renal survival
- Discrimination (time-dependent ROC): RRS model better than Berden's classification for 0.5-, 1- and 3-year renal survival
- Calibration: RRS model worse than Berden's classification for 1- and 3-year renal survival
- Decision curve analysis: RRS achieved more clinical benefit than Berden's classification for 0.5-, 1- and 3-year renal survival
Observational data: associations, not effects.
Further findings
End-stage renal disease (ESRD) (whole cohort) · median follow-up 38.99 months
- Patients developing ESRD
- 32.44%
Renal survival across classes (Kaplan-Meier)
- Significant differences among groups by Berden's classification or RRS
- both log-rank p<0.001
Original publication
The predictive value of Berden's classification versus renal risk score for renal survival of Chinese patients with myeloperoxidase-anti-neutrophil cytoplasmic antibody-associated glomerulonephritis. Clin Exp Rheumatol. Published 8 September 2022. doi:10.
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