Vasculitis & polymyalgia rheumatica
Epidemiology and treatment outcome of ANCA-associated vasculitis in South Korea: a nationwide, population-based cohort study
Authors' conclusion
In South Korea, the incidence of MPA has increased over time. Although both GPA and MPA had high rates of mortality and morbidity, MPA has a poorer prognosis than GPA.
Study context
- Population
- Entire Korean population, Korean National Health Insurance Service database and Rare Intractable Disease registry, 2010–2018
- Exposure
- Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) vs matched general-population comparator
- GPAn = 546
- MPAn = 795
- Outcome
- Incidence and prevalence rates of GPA and MPA and trends over time
Methodological detailsnationwide, matched comparator (nearest-neighbour by age, sex, income and comorbidity index, 5:1)
- Nationwide
- Matched comparator (nearest-neighbour by age, sex, income and comorbidity index, 5:1)
Main finding
As reported in the abstract
Incidence of GPA and MPA · 2010-2018
- Incidence of both diseases increased with age, peak among patients aged ≥70 years
- Incidence of MPA increased continuously over time; GPA showed no significant changes
Observational data: associations, not effects.
Further findings
| Outcome | GPA | MPA | HR |
|---|---|---|---|
| Mortality during observation periodGPA vs Comparator | 28.7% | 41.1% | 4.02 |
| Standardised mortality ratio vs general population | 3.53 | 5.58 | |
| Mortality during observation periodMPA vs Comparator | 5.64 |
Mortality and morbidity (renal replacement therapy, ICU admission), MPA vs GPA
- Higher mortality and morbidity rates in MPA than in GPA
Original publication
Epidemiology and treatment outcome of ANCA-associated vasculitis in South Korea: a nationwide, population-based cohort study. Clin Exp Rheumatol. Published 26 December 2023. doi:10.
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