Vasculitis & polymyalgia rheumatica
Shelterin dysfunction promotes CD4+ T cell senescence in Behçet’s disease
Authors' conclusion
Our study demonstrated that TRF2 deficiency in BD naïve CD4+ T cells promoted cell apoptosis and senescence, leading to proinflammatory cytokines overproduction.
Study context
- Population
- Naïve CD4+ T cells from Behçet's disease (BD) patients and sex- and age-matched healthy controls
- Participants
- 40 vs 40
- Comparison
- BD patients vs healthy controls
- BDn = 40
- Healthy controls (HC)n = 40reference
- Outcome
- Naïve CD4+ T cell senescence, shelterin and DDR, BD vs HC
Methodological detailscase-control, sex- and age-matched, TRF2 silencing validation
- Case-control
- Sex- and age-matched
- TRF2 silencing validation
Main finding
As reported in the abstract
- BD: significantly decreased naïve CD4+ T cells, increased apoptosis, senescence and TNF-α and IFN-γ production upon activation vs HC
- BD naïve CD4+ T cells: shortened telomere, impaired telomerase activity
- BD naïve CD4+ T cells: lower expression of shelterin subunits TRF2, TIN2 and RAP1
- BD naïve CD4+ T cells: significantly increased DNA damage response (DDR) (elevated pATM, pp53 and p21)
- TRF2 silencing in HC naïve CD4+ T cells markedly upregulated DDR, apoptosis and proinflammatory cytokine production
Original publication
Shelterin dysfunction promotes CD4+ T cell senescence in Behçet’s disease. Rheumatology (Oxford). Published 25 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →