Vasculitis & polymyalgia rheumatica
The transcriptional profiling identifies hub genes in immune subsets of patients with Behçet's syndrome
Authors' conclusion
Our findings provide novel insights into the immune subsets related to the biological process in BS
Study context
- Population
- Patients with Behçet's syndrome and healthy controls; CD14+ monocytes and CD4+ T cells from Gene Expression Omnibus (GEO) dataset GSE61,399
- Comparison
- BD vs healthy controls
- Outcome
- Hub genes and biological processes (DEGs) in immune subsets
Methodological detailsbioinformatic analysis of public expression profiles (GSE61399), Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment, protein-protein interaction (PPI) network (Search Tool for the Retrieval of Interacting Genes (STRING), Cytoscape Molecular Complex Detection (MCODE))
- Bioinformatic analysis of public expression profiles (GSE61399)
- GO and KEGG enrichment
- PPI network (STRING, Cytoscape MCODE)
Main finding
As reported in the abstract
Differential expression genes (DEGs) in CD14+ monocytes
102
DEGs in CD4+ T cells
48
Original publication
The transcriptional profiling identifies hub genes in immune subsets of patients with Behçet's syndrome. Clin Exp Rheumatol. Published 18 May 2022. doi:10.
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