Lupus & antiphospholipid syndrome
Maternal Anti‐Ro Antibody Titers Obtained With Commercially Available Immunoassays Are Strongly Associated With Immune‐Mediated Fetal Heart Disease
Main finding · CNL event rate by anti-Ro 60 titer, group 1 mothers with additional testing (n=122; 9 CNL)Result — go to the resultOdds ratio 13.1Authors' conclusion
CNL is associated with substantially higher anti-Ro antibody titers than are obtained using a standard CIA.
Study context
- Population
- Anti-Ro antibody-positive mothers referred since 2018 for fetal echocardiography27 mothers with fetal CNL
- Participants
- 240 vs 18
- Exposure
- Anti-Ro 60 antibody titer categories in anti-Ro-positive mothers
- Group 1n = 240
- Group 2n = 18
- Outcome
- Association between maternal anti-Ro antibody titers and fetal cardiac manifestations of neonatal lupus (CNL)
Main finding
As reported in the abstract
CNL event rate by anti-Ro 60 titer, group 1 mothers with additional testing (n=122; 9 CNL)
Odds ratio
13.1
P = 0.0008
Events by group
Observational data: associations, not effects.
Further findings
Anti-Ro 60 titer distribution, group 2 mothers with primary CNL diagnosis
Original publication
Maternal Anti‐Ro Antibody Titers Obtained With Commercially Available Immunoassays Are Strongly Associated With Immune‐Mediated Fetal Heart Disease. Arthritis Rheumatol. Published 11 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →