Lupus & antiphospholipid syndrome
Prevalence of migraine in systemic lupus erythematosus: A meta-analysis
Pooled resultResult — go to the resultOdds ratio 1.964 95% CI 1.512–2.550Authors' conclusion
About one-third of SLE patients experience migraine worldwide. The prevalence of migraine is more frequent in SLE patients than the healthy controls.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients and healthy controls in reports with disclosed migraine diagnosis criteria; literature searched to January 21, 202317 reports
- Participants
- 2,901 vs 575
- Comparison
- SLE patients vs healthy controls
- SLEn = 2,901
- HCn = 575reference
- Outcome
- Prevalence of migraine in SLE patients worldwide, and whether migraine is more prevalent in SLE than controls
Methodological detailsEgger's regression and funnel plots for publication bias, Cochrane Q and I2 for heterogeneity
- Egger's regression and funnel plots for publication bias
- Cochrane Q and I2 for heterogeneity
Pooled result
As reported in the abstract
Odds ratio
1.964
95% CI 1.512–2.550
P = 0.000
SLEvs HC
OR 1.964 (95% CI 1.512–2.550); P = 0.000
- Pooled prevalence of migraine
- 34.8%
Further pooled results
| Outcome | SLE | OR (95% CI) | P value | |
|---|---|---|---|---|
| Migraine prevalence incl. 10 further reports without disclosed migraine diagnosis criteria (27 reports; SLE 3473, HC 741) | 33.5% | 2.107 (1.672–2.655) | P = 0.000 | |
| 0.20.5125Odds ratio (log scale) |
- Migraine prevalence in SLE patients from South America (subgroup)
- 56.2%
Original publication
Prevalence of migraine in systemic lupus erythematosus: A meta-analysis. Lupus. Published 7 June 2023. doi:10.
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