Lupus & antiphospholipid syndrome
Arterial stiffness tested by pulse wave velocity and augmentation index for cardiovascular risk stratification in antiphospholipid syndrome
Authors' conclusion
APS patients exhibit elevated AIx@75 vs HC and similar to DM patients, indicating enhanced arterial stiffening in APS.
Study context
- Population
- Patients with thrombotic Antiphospholipid syndrome (APS) (70.9% female, mean age 45.4 years), age/sex-matched diabetes mellitus (DM) patients and healthy controls (HC)age/sex matched
- Participants
- 110 / 110 / 110
- Exposure
- Thrombotic APS vs DM vs healthy controls
- APSn = 110
- DMn = 110
- HCn = 110reference
- Outcome
- Arterial stiffness: carotid-femoral pulse wave velocity (cfPWV) and augmentation index normalized to 75 beats/min (AIx@75), SphygmoCor device
Methodological detailsage/sex matched, linear regression
- Age/sex matched
- Linear regression
Main finding
As reported in the abstract
Arterial stiffness (cfPWV, AIx@75), adjusted for age, sex, CV risk factors and plaque presence
Β (carotid-femoral pulse wave velocity (cfPWV))
−0.142
95% CI −0.514 to 0.230P = 0.454
similar cfPWV
Β (AIx@75)
4.525
95% CI 1.372–7.677P = 0.005
increased AIx@75
Observational data: associations, not effects.
Further findings
Independent determinants of cfPWV in APS
| β (95% CI) | P value | |
|---|---|---|
| Age | 0.056 (0.034–0.078) | P < 0.001 |
| MAP | 0.070 (0.043–0.097) | P < 0.001 |
| Atherosclerotic femoral plaques | 0.732 (0.053–1.411) | P = 0.035 |
| Anti-β2-glycoprotein I IgM positivity | 0.696 (0.201–1.191) | P = 0.006 |
Determinants of AIx@75 in APS
| β (95% CI) | P value | |
|---|---|---|
| Age | 0.334 (0.117–0.551) | P = 0.003 |
| Female sex | 7.447 (2.312–12.581) | P = 0.005 |
| MAP | 0.425 (0.187–0.663) | P = 0.001 |
Original publication
Arterial stiffness tested by pulse wave velocity and augmentation index for cardiovascular risk stratification in antiphospholipid syndrome. Rheumatology (Oxford). Published 9 June 2023. doi:10.
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