Lupus & antiphospholipid syndrome
Prospective Evaluation of High Titer Autoantibodies and Fetal Home Monitoring in the Detection of Atrioventricular Block Among Anti‐SSA/Ro Pregnancies
Authors' conclusion
High-titer antibodies are associated with an increased incidence of AVB.
Study context
- Population
- Pregnant women with anti-SSA/Ro autoantibodies by commercial testing
- Participants
- 413 women
- Exposure
- High vs low anti-52-kD and/or 60-kD SSA/Ro titers
- High titern = 261
- Outcome
- Fetal second-degree AVB
Methodological detailsstratified by anti-52-kD and/or 60-kD SSA/Ro titer, ambulatory fetal heart rate and rhythm monitoring
- Stratified by anti-52-kD and/or 60-kD SSA/Ro titer
- Ambulatory fetal heart rate and rhythm monitoring
Main finding
As reported in the abstract
Fetal AVB frequency
High titer
3.8%
Low titer
0
events
Observational data: associations, not effects.
Further findings
Atrioventricular block (AVB) incidence, top quartile anti-60-kD SSA/Ro
- Top quartile anti-60-kD SSA/Ro
- 7.7%
- Top quartile with previous child with AVB
- 27.3%
Titers in paired AVB and non-AVB pregnancies
- Healthy pregnancies not explained by decreased titers (15 participants with paired samples)
FHRM performance
- Abnormal FHRM recordings
- 45 of 30,920
- Confirmed AVB by urgent echocardiogram
- 10
- Second-degree AVB, all <12 hours from normal FHRM
- 7
- Surveillance echocardiograms detected no AVB when preceding FHRM normal
- One second/third-degree and two third-degree AVB diagnosed >17 to 72 hours from an FHRM
Original publication
Prospective Evaluation of High Titer Autoantibodies and Fetal Home Monitoring in the Detection of Atrioventricular Block Among Anti‐SSA/Ro Pregnancies. Arthritis Rheumatol. Published 10 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →