Systemic sclerosis & Raynaud's
Longitudinal global transcriptomic profiling of preclinical systemic sclerosis reveals molecular changes associated with disease progression
Authors' conclusion
Participants with PreSSc had a distinct gene expression profile indicating that molecular differences at a transcriptomic level are already present in the preclinical stages of SSc. Furthermore, a reduced NK signature in PBCs was related to SSc progression over time.
Study context
- Population
- Participants with preclinical SSc (PreSSc) and healthy controls; PBC global gene expression at baseline and follow-up (mean 4.2 years)mean follow-up 4.2 years
- Participants
- 33 / 16 / 14 / 19
- Exposure
- PreSSc vs healthy controls; evolving vs stable PreSSc at follow-up
- PreSScn = 33
- Healthy controls (HCs)n = 16reference
- Evolving PreSScn = 14
- Stable PreSScn = 19reference
- Outcome
- Baseline PBC transcriptome, PreSSc vs HCs
- Follow-up
- Baseline
Methodological detailslongitudinal, RNA sequencing, modular analysis
- Longitudinal
- RNA sequencing
- Modular analysis
Main finding
As reported in the abstract
Differentially expressed genes
2889
Modules significantly decreased in PreSSc (lymphoid lineage, cytotoxic/NK cell, erythropoiesis)
10
Observational data: associations, not effects.
Further findings
- Progression at follow-up · follow-up (mean 4.2 years) — Evolving PreSSc
- 42.4%
Progression at follow-up · follow-up (mean 4.2 years)
- Progression not associated with baseline clinical features or baseline PBC transcript modules
Transcript modules at follow-up
- Differentially expressed transcripts, change follow-up vs baseline, stable vs evolving PreSSc (336 up, 213 down), EIF2 signalling upregulated
- 549
- Stable PreSSc normalised down-regulated cytotoxic/NK cell and protein synthesis modules; evolving PreSSc kept their down-regulation
Original publication
Longitudinal global transcriptomic profiling of preclinical systemic sclerosis reveals molecular changes associated with disease progression. Rheumatology (Oxford). Published 30 August 2022. doi:10.
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