Systemic sclerosis & Raynaud's
Proteomic aptamer analysis reveals serum markers that characterize preclinical systemic sclerosis (SSc) patients at risk for progression toward definite SSc
Authors' conclusion
A distinct protein profile characterized PreSSc from HCs and proteins associated with hypoxia, vasculopathy, and fibrosis regulation are linked with the progression from preclinical to definite SSc.
Study context
- Population
- Patients with preclinical SSc (discovery cohort 13; independent validation cohort 50) and matched healthy controls (HCs)13 PreSSc discovery
- Exposure
- PreSSc progressing to definite SSc vs non-progressing PreSSc; PreSSc vs HCs (discovery)
- HCsn = 8reference
- Outcome
- Progression to definite SSc (EULAR/ACR 2013 classification criteria)
- Follow-up
- Up to 5 years (validation cohort)
Methodological detailsdiscovery/validation two-step approach, SOMAscan aptamer-based proteomic analysis, age, gender and ethnicity matched HCs, time-to-event analysis for interval-censored data
- Discovery/validation two-step approach
- SOMAscan aptamer-based proteomic analysis
- Age, gender and ethnicity matched HCs
- Time-to-event analysis for interval-censored data
Main finding
As reported in the abstract
Association of baseline serum proteins with progression to definite SSc (validation cohort)
Endostatin, HR (CI95 2.2-47.59), p=0.003
10.23
bFGF, HR (CI95 0.709-0.996), p=0.045
0.84
PAF-AHβ, HR (CI95 0.171-0.809), p=0.013
0.372
Observational data: associations, not effects.
Further findings
Discovery cohort: proteins differentially expressed vs HCs
- Proteins differentially expressed vs HCs, out of 1306 analysed
- 286
- Proteins significantly associated with disease progression
- Ten
- Enriched pathways: angiogenesis, endothelial cell chemotaxis, endothelial cell chemotaxis to fibroblast growth factor (FGF)
Original publication
Proteomic aptamer analysis reveals serum markers that characterize preclinical systemic sclerosis (SSc) patients at risk for progression toward definite SSc. Arthritis Res Ther. Published 27 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →