Systemic sclerosis & Raynaud's
A data-driven approach finds RNA polymerase III antibody and tendon friction rubs as enrichment tools for early diffuse scleroderma trials
Authors' conclusion
Adjustment for both RNAP3 and TFR predicts mRSS trajectory and diminished the mRSS decline in ASSET placebo group, and identified significant differences in CRISS.
Study context
- Population
- Patients with early diffuse SSc first seen at the University of Pittsburgh, 1980–2015, with ≥3 visits and at least two modified Rodnan skin score (mRSS) scores within the first year403 <18 months, 514 <36 months disease duration
- Outcome
- Predictors of mRSS trajectory
- Follow-up
- 5 years
Methodological detailssingle-centre, group-based trajectory analysis, multivariable regression, classification tree analysis, applied to ASSET trial data
- Single-centre
- Group-based trajectory analysis
- Multivariable regression
- Classification tree analysis
- Applied to ASSET trial data
Main finding
As reported in the abstract
Predictors of mRSS trajectory over 5 years
- Skin thickness progression rate, RNAP3 antibody positivity and tendon friction rubs (TFR) identified by all methods as predictors of mRSS trajectory and potential enrichment variables
Observational data: associations, not effects.
Further findings
mRSS follow-up scores per patient
- Median number of mRSS follow-up scores
- 14 (IQR 8, 25)
ASSET placebo mRSS response with adjustment for RNAP3 and TFR · 6 months
- Adjustment for both RNAP3 and TFR reduced the placebo mRSS response, particularly at 6 months
ACR Composite Response Index in Systemic Sclerosis (CRISS) score in ASSET with adjustment · 6 and 12 months
- Significant difference with adjustment by RNAP3 at 6 months, and by TFR or RNAP3 at 12 months
Original publication
A data-driven approach finds RNA polymerase III antibody and tendon friction rubs as enrichment tools for early diffuse scleroderma trials. Rheumatology (Oxford). Published 29 August 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →