Systemic sclerosis & Raynaud's
Circulating CTRP9 Is Associated With Severity of Systemic Sclerosis–Associated Interstitial Lung Disease
Authors' conclusion
Higher circulating CTRP9 associated with worse pulmonary function, while low CTRP9 identified patients with lung disease stability over time.
Study context
- Population
- Systemic sclerosis (SSc) patients, Northwestern Scleroderma Program Patient Registry and Biorepository; PFT data at 12-month intervals to 48 months
- Participants
- 110 patients
- Exposure
- High vs low circulating CTRP9
- Outcome
- Longitudinal trajectory of FVC% predicted
- Follow-up
- 48 months
Methodological detailslongitudinal, mixed model, latent trajectory analysis
- Longitudinal
- Mixed model
- Latent trajectory analysis
Main finding
As reported in the abstract
FVC% trajectory by CTRP9 group (mixed model)
- High CTRP9 associated with worse lung function but not with a different trajectory
- High CTRP9 vs Low CTRP9: P = 0.23
Observational data: associations, not effects.
Further findings
| Outcome | High CTRP9 | Low CTRP9 | P value |
|---|---|---|---|
| FVC% at baseline (cross-sectional) | 72% (SD 17) | 80% (SD 18) | P = 0.02 |
| FVC% at 48 months (cross-sectional) | 68 (SD 19) | 84 (SD 18) | P = 0.001 |
- Low CTRP9 identifying stability of lung disease
- 73% · sensitivity
Latent trajectory analysis
- Confirmed association of lower CTRP9 with higher FVC%
Original publication
Circulating CTRP9 Is Associated With Severity of Systemic Sclerosis–Associated Interstitial Lung Disease. Arthritis Care Res (Hoboken). Published 24 August 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →