Systemic sclerosis & Raynaud's
Association of endothelial to mesenchymal transition and cellular senescence with fibrosis in skin biopsies of systemic sclerosis patients: a cross-sectional study
Authors' conclusion
EndMT and fibroblast senescence were more abundant in skin biopsies from SSc patients.
Study context
- Population
- Archival skin biopsies from systemic sclerosis (SSc) patients and controls
- Participants
- 18 vs 4
- Exposure
- SSc vs controls
- SScn = 18
- Controlsn = 4reference
- Outcome
- Associations of dermal fibrosis, fibroblast senescence and EndMT in SSc skin biopsies
Methodological detailsarchival skin biopsies
- Archival skin biopsies
Main finding
As reported in the abstract
- Histological dermal fibrosis score correlated with modified Rodnan skin score
- rho 0.55, p=0.042
- Endothelial to mesenchymal transition (EndMT) more abundant in SSc skin than controls
- p<0.01
Observational data: associations, not effects.
Original publication
Association of endothelial to mesenchymal transition and cellular senescence with fibrosis in skin biopsies of systemic sclerosis patients: a cross-sectional study. Clin Exp Rheumatol. Published 30 August 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →