Sjögren's disease & overlap diseases
Longitudinal evaluation of major salivary gland functioning in Sjögren's disease patients in a prospective standard-of-care cohort
Authors' conclusion
Overall, major salivary gland functioning assessed with SGUS, sialometry and PROMs did not change significantly up to 5 years of follow-up in a standard-of-care cohort of SjD patients from daily clinical practice.
Study context
- Population
- Consecutive outpatients with primary Sjögren's disease (SjD) fulfilling ACR-EULAR classification criteria, RESULT cohort75 reached Y5
- Participants
- 253 outpatients
- Outcome
- Changes in major salivary gland functioning (SGUS Hocevar and OMERACT scores, sialometry, PROMs)
- Follow-up
- BL, Y2 and Y5
Methodological detailslongitudinal, standard-of-care cohort, consecutive outpatients
- Longitudinal
- Standard-of-care cohort
- Consecutive outpatients
Main finding
As reported in the abstract
SGUS Hocevar score · BL, Y2, Y5
- Hocevar mean±SD at baseline (BL)
- 22±10
- Hocevar mean±SD at Y2
- 22±10
- Hocevar mean±SD at Y5
- 23±10
- Salivary gland ultrasonography (SGUS) Hocevar, OMERACT scores, UWS, SWS and patient-reported outcome measures (PROMs) stable over time
- all p>0.05
Observational data: associations, not effects.
Further findings
Submandibular/sublingual saliva at Y5
- Slightly decreased uSMSLS
- P = 0.025
- Slightly decreased sSMSLS
- P = 0.004
Individual patient-level change ≥25%
- Similar proportion showed increase or decrease of ≥25% for Hocevar, UWS and SWS
Associations of objective assessments with PROMs
- At BL, poor associations between SGUS and PROMs; fair between sialometry and PROMs
- Over time, changes in objective assessments did not correlate with changes in PROMs
Original publication
Longitudinal evaluation of major salivary gland functioning in Sjögren's disease patients in a prospective standard-of-care cohort. Clin Exp Rheumatol. Published 26 December 2023. doi:10.
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